A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping.

A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping.

We use in situ Hi-C to probe the 3D structure of genomes, developing haploid and diploid maps of 9 cell sorts. The densest, in human lymphoblastoid cells, incorporates 4.9 billion contacts, reaching 1 kb resolution. We discover that genomes are partitioned into contact domains (median size, 185 kb), that are related to distinct patterns of …

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