Sat. Apr 27th, 2024

Kilobase Snakes

موسوعة عالم الثعابين

Comparative venom gland transcriptomics of Naja kaouthia (monocled cobra) from Malaysia and Thailand: elucidating geographical venom variation and insights into sequence novelty.

BACKGROUNDThe monocled cobra (Naja kaouthia) is a medically important venomous snake in Southeast Asia. Its venom has been shown to vary geographically in relation to venom composition and neurotoxic activity, indicating vast diversity of the toxin genes within the species. To investigate the polygenic trait of the venom and its locale-specific variation, we profiled and compared the venom gland transcriptomes of N. kaouthia from Malaysia (NK-M) and Thailand (NK-T) applying next-generation sequencing (NGS) technology.

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TH1-Like (Drosophila) (TH1L) Antibody
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Description: ELISA

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Description: ELISA

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Description: ELISA

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E01A34712 96T
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Description: ELISA

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Description: ELISA

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Description: ELISA

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Description: ELISA

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Description: ELISA

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Inositol Is
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Description: Inositol Is

Phalaenopsine Is
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IS-159
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IS-159
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Description: IS-159

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Lenti ORF clone of Human TH1-like (Drosophila) (TH1L), transcript variant 1, Myc-DDK-tagged
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3`UTR clone of TH1-like (Drosophila) (TH1L) transcript variant 1 for miRNA target validation
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Mouse Th1 Cytokine Kit (4-plex) (Flow Cytometry Multiplex Bead Assay, Non-Magbeads)
FCM-C10R 96tests
EUR 856
Description: T helper cells (Th) play a vital role in the adaptive immune system by suppressing or regulating immune responses. After Th actived, it will differentiate into T-helper 1 (Th1) or T-helper 2 (Th2) effector cells. These two subsets are characterized by their distinct cytokine expression pattern and the immune function they mediate. Th1 and Th2 cells each produce a specialized combination of cytokines that depends on type of pathogen that the helper T cell has recognized—some cytokines are more effective than others in the process of eliminating certain invaders. In general, TH1 cytokines play the role of immune killing, while Th2 cytokines play the role of immune protection. Th1/Th2 paradigm provides rationale for developing new vaccines against infectious diseases and novel strategies for the therapy of allergic and autoimmune disorders.

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Ebro EBI 20-TH1 Standard Temperature / Humidity Data Logger - with internal humidity sensor - Set and accessories - EACH
THE1074 EACH
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Lenti ORF particles, Nelfcd (Myc-DDK-tagged) - Mouse TH1-like homolog (Drosophila) (Th1l), 200ul, >10^7 TU/mL
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Lenti ORF particles, NELFCD (mGFP-tagged) - Human TH1-like (Drosophila) (TH1L), transcript variant 1, 200ul, >10^7 TU/mL
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Lenti ORF particles, NELFCD (Myc-DDK tagged) - Human TH1-like (Drosophila) (TH1L), transcript variant 1, 200ul, >10^7 TU/mL
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5-CARBOXYTetramethylrhodamine, SINGLE IS
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Rabbit IS ELISA Kit
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Whatman ME 2521 ST 47mm
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Whatman ME 2521 ST 50mm
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Whatman ME 2521 ST 47mm - PK100
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METHODSThe transcriptomes were sequenced on the Illumina HiSeq platform, assembled and followed by transcript clustering and annotations for gene expression and function. Pairwise or multiple sequence alignments were conducted on the toxin genes expressed. Substitution rates were studied for the major toxins co-expressed in NK-M and NK-T.

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