Complete nucleotide sequence of a 43-kilobase genomic island associated with the multidrug resistance region of Salmonella enterica serovar Typhimurium DT104 and its identification in phage type DT120 and serovar Agona.

Complete nucleotide sequence of a 43-kilobase genomic island associated with the multidrug resistance region of Salmonella enterica serovar Typhimurium DT104 and its identification in phage type DT120 and serovar Agona.

This examine describes the characterization of the lately described Salmonella genomic island 1 (SGI1) (D. A. Boyd, G. A. Peters, L.-Okay. Ng, and M. R. Mulvey, FEMS Microbiol. Lett. 189:285-291, 2000), which harbors the genes associated with the ACSSuT phenotype in a Canadian isolate of Salmonella enterica serovar Typhimurium DT104. A 43-kb region has been …

Complete nucleotide sequence of a 43-kilobase genomic island associated with the multidrug resistance region of Salmonella enterica serovar Typhimurium DT104 and its identification in phage type DT120 and serovar Agona. Read More »

Drosophila melanogaster mutations suppressible by the suppressor of Hairy-wing are insertions of a 7.3-kilobase mobile element.

Drosophila melanogaster mutations suppressible by the suppressor of Hairy-wing are insertions of a 7.3-kilobase mobile element.

Certain spontaneous mutations of Drosophila melanogaster are suppressed by su(Hw), the suppressor of Hairy-wing (3R-54.8). We discover that mutations suppressible by su(Hw) end result from insertions of a mobile ingredient at the affected loci. The ingredient, named gypsy, is roughly 7.three kilobases lengthy and contains 0.5-kilobase direct terminal repeats. It was first recognized in DNA …

Drosophila melanogaster mutations suppressible by the suppressor of Hairy-wing are insertions of a 7.3-kilobase mobile element. Read More »

A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping.

A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping.

We use in situ Hi-C to probe the 3D structure of genomes, developing haploid and diploid maps of 9 cell sorts. The densest, in human lymphoblastoid cells, incorporates 4.9 billion contacts, reaching 1 kb resolution. We discover that genomes are partitioned into contact domains (median size, 185 kb), that are related to distinct patterns of …

A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping. Read More »

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